Effect of Buchanania lanzan Spreng. bark extract on cyclophosphamide induced genotoxicity and oxidative stress in mice

OBJECTIVE@#To elucidate the effect of ethanolic extract of Buchanania lanzan Spreng. (B. lanan) bark against cyclophosphamide induced genotoxicity and oxidative stress in mice.@*METHODS@#The prevalence of micronuclei in bone marrow, the extent of lipid peroxidation, reduced glutathione and the status of the antioxidant enzymes, superoxide dismutase and catalase in liver of mice were used as intermediate biomarkers for chemoprotection. Lipid peroxidation and associated compromised antioxidant defenses in cyclophosphamide treated mice were observed in the liver.@*RESULTS@#Pre-treatment with B. lanzan 250, 500 and 1,000 mg/kg, p.o., daily for 7 days significantly reduced the chromosomal damage and lipid peroxidation with concomitant changes in antioxidants and detoxification systems.@*CONCLUSIONS@#These results point out the presence of chemopreventive phytoconstituents in the crude extract offering protection against cyclophosphamide induced genotoxicity and oxidative stress in mice.

Antibacterial activity and physicochemical evaluation of roots of Butea monosperma

Objective: To evaluate the antibacterial activity of the petroleum ether extract of root of Buteamonosperma B. monosperma was studied against Staphylococcus faecalis (S. faecalis), Sterptococcus faecalis (S. faecalis), Aeromonas hydrophilia (A. hydrophilia), Salmonela typhae (S. typhae), Stphylococcus cohni (S. cohni), Escherichia coli (E. coli) and Serratia ficaria (S. ficaria) by using well diffusion method. Results: Petroleum ether extract of root of B. monosperma exhibited a prominent inhibitory effect against bacterial strains. Conclusion: From the result it can be concluded that the B. monosperma extract has potent in vitro antibacterial activity. (B. monosperma). Method: In vitro antibacterial activity of petroleum ether i.e.